HEALTH IN PREGNANCY AND POSTPARTUM (HIPP)

FUNDING SOURCE: National Institutes of Health (NICHD) (2014-2022)

PRINCIPAL INVESTIGATORS:

CO-INVESTIGATORS:

Nearly three-quarters of African American women and half of non-Hispanic White women of childbearing ages in the US are overweight or obese. About one-half (46%) of pregnant women exceed gestational weight gain recommendations. This problem is significant because excessive gestational weight gain is a strong risk factor for new or persistent obesity in women and increases a woman’s risk for maternal complications. Furthermore, accumulating observational studies show that higher maternal gestational weight gain is associated with higher offspring birth weight, which persists in childhood, adolescence, and young adulthood. Novel intervention approaches have the potential to help overweight/obese financially disadvantaged women achieve healthy weight control during and after pregnancy and improve the health of their offspring. We will build on our promising R21 feasibility study to address the following specific aims: (1) examine the impact of a lifestyle intervention on gestational weight gain and postpartum weight loss in overweight and obese women, (2) examine the impact of the intervention on physical activity (PA), dietary intake, and quality of life (QOL), (3) examine race differences in total gestational weight gain, PA, dietary intake, and QOL; and (4) examine the impact of the intervention on offspring adiposity. Pregnant women (N=500) women, half African American and half White, will be recruited from obstetric clinics in the greater Columbia, South Carolina area and randomized to a lifestyle intervention (n=250) or standard care (n=250). The lifestyle intervention, grounded in Social Cognitive Theory, will target regular body weight self-monitoring and increasing PA and healthy dietary practices in pregnancy and postpartum. The lifestyle program will start within 15 wks gestation and will continue through 6 mos postpartum. All women will be assessed early in pregnancy (≤13 wks), at 32 wks gestation, and at 6- and 12-mos postpartum, and offspring will be assessed at 6- and 12-mos.

PUBLICATIONS:

Lane, A., Wilcox, S., Wingard, E., McLean, M. K., & Liu, J. (2023). Association of a lifestyle intervention with blood pressure trajectories during pregnancy and postpartum in women with pre-pregnancy overweight and obesity. Maternal and Child Health Journal, 27(8), 1407–1415.
DOI: 10.1007/s10995-023-03709-1
Abstract: https://pubmed.ncbi.nlm.nih.gov/37266858/

Day, K. R., Wilcox, S., Liu, J., & Zahnd, W. E. (2023). Associations between neighborhood crime and physical activity among pregnant women in South Carolina. Preventing Chronic Disease, 20, E29.
DOI: 10.5888/pcd20.220239
Abstract: https://pubmed.ncbi.nlm.nih.gov/37079752/

Liu, J., Wilcox, S., Hutto, B., Turner-McGrievy, G., & Wingard, E. (2022). Effects of a lifestyle intervention on postpartum weight retention among women with elevated weight. Obesity (Silver Spring), 30(7), 1370–1379.
DOI: 10.1002/oby.23449
Abstract: https://pubmed.ncbi.nlm.nih.gov/35722816/

Wilcox, S., Liu, J., Turner-McGrievy, G., Boutté, A., Wingard, E. (2022). Effects of a behavioral intervention on physical activity, diet, and health-related quality of life in pregnant women with elevated weight: Results of the HIPP randomized controlled trial. International Journal of Behavioral Nutrition and Physical Activity, 19(1), 145.
DOI: 10.1186/s12966-022-01387-w
Abstract: https://pubmed.ncbi.nlm.nih.gov/36494702/

Wilcox, S., Dahl, A.A., Boutte, A.K., Liu, J., Day, K., Turner-McGrievy, G., Wingard, E. (2022). Process evaluation methods and results from the Health in Pregnancy and Postpartum (HIPP) randomized controlled trial. BMC Pregnancy and Childbirth, 22(1), 794.
DOI: 10.1186/s12884-022-05107-x
Abstract: https://pubmed.ncbi.nlm.nih.gov/36289464/

Liu, J., Wilcox, S., Hutto, B., Turner-McGrievy, G., & Wingard, E. (2022). Effects of a lifestyle intervention on postpartum weight retention among women with elevated weight. Obesity (Silver Spring, Md.), 30(7), 1370–1379.
DOI: 10.1002/oby.23449
Abstract: https://pubmed.ncbi.nlm.nih.gov/35722816/

Liu, J., Wilcox, S., Wingard, E., Turner-McGrievy, G.M., Hutto, B., Burgis, J.A. (2021). A behavioral lifestyle intervention to limit gestational weight gain in pregnant women with overweight and obesity. Obesity, 29(4), 672-680. Epub ahead of print February 22, 2021.
DOI: 10.1002/oby.23119
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33619910

Lane-Cordova, A.D., Wilcox, S., Fernhall, B., Liu, J. (2021). Agreement between blood pressure from research study visits versus electronic medical records and associations with hypertensive disorder diagnoses in pregnant women with overweight/obesity. Blood Pressure Monitoring Research, 26(5), 314-347. Epub ahead of print May 7, 2021.
DOI: 10.1097/MBP.0000000000000542
Abstract: https://pubmed.ncbi.nlm.nih.gov/34001756/

Boutté, A.K., Turner-McGrievy, G.M., Wilcox, S., Liu, J., Eberth, J.M., Kaczynski, A.T. (2021). Stress and depressive symptoms are not associated with overall diet quality, but are associated with aspects of diet quality in pregnant women in South Carolina. Journal of the Academy of Nutrition and Dietetics, 121(9), 1785-1792.
DOI: 10.1016/j.jand.2021.02.025
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33858775

Boutté, A. K., Turner-McGrievy, G. M., Wilcox, S., Liu, J., Eberth, J. M., Kaczynski, A. T. (2021). Associations of maternal stress and/or depressive symptoms with diet quality during pregnancy: A narrative review. Nutrition Reviews, 79(5), 495-517. Epub ahead of print June 29, 2020.
DOI: 10.1093/nutrit/nuaa019
Abstract: https://pubmed.ncbi.nlm.nih.gov/32529223/

Boutté, A.K., Turner-McGrievy, G.M., Eberth, J.M., Wilcox, S., Liu, J., Kaczynski, A.T. (2021). Healthy food density is not associated with diet quality among pregnant women with overweight/obesity in South Carolina. Journal of Nutrition Education and Behavior, 53(2), 120-129.
DOI: 10.1016/j.jneb.2020.11.014
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/33573765

Liu, J., Wilcox, S., Wingard, E., Burgis, J.T., *Schneider, L., *Dahl, A. (2020). Strategies and challenges in recruiting pregnant women with elevated body mass index for a behavioral lifestyle intervention. Women’s Health Reports,1(1), 556-565.
DOI: 10.1089/whr.2020.0089
Abstract: https://www.liebertpub.com/doi/abs/10.1089/whr.2020.0089

Wilcox, S., Liu, J., Addy, C.L., Turner-McGrievy, G., Burgis, J.T., Wingard, E., Dahl, A.A., Whitaker, K.M., Schneider, L., Boutté, A.K.  (2018). A randomized controlled trial to prevent excessive gestational weight gain and promote postpartum weight loss in overweight and obese women: Health In Pregnancy and Postpartum (HIPP). Contemporary Clinical Trials, 66, 51-63.  PMID: 29371061